This work focuses on variations of the Earth tidal factor and phase lag derived from groundwater observations before and after major earthquakes. It is based on an analysis of the data from four observational wells at boundaries between distinct active blocks of China mainland. These wells are also situated on several active fault zones and have exhibited considerable respon-ses to the Wenchuan Ms8.0 earthquake of 2008 in China. We collected hourly records of water levels of these wells from 2007 to 2009 and processed these data for analysis. The tidal factors, phase lags, and phase-difference changes of tidal residuals of each well were calculated. We found that when the Wenchuan quake happened, the tidal factors of the 4 wells were changing rapidly, while their phase lags and phase differences of tidal residuals declined swiftly, which may reflect the stress and strain changes of the well-aquifer system during the seismic generation.