Based on deep geophysical detections, we have reconstructed the crustal structure from the eastern margin of the Tibetan Plateau to the Jiangnan-Xuefeng orogenic belt. The results suggest that the Yangtze Block was overthrusted by crustal materials in its NW direction from the eastern Tibetan Plateau but in its SE direction from the Jiangnan orogen. These overthrusting effects control the crustal structure from the western Sichuan to the western area of the Jiangnan orogen-Xuefeng orogenic belt. The eastward extruded materials from the eastern Tibetan Plateau were blocked by the rigid basement in the Sichuan Basin, where upper-middle crust was overthrusted whereas the lower crust was underthrusted beneath the Sichuan Basin. The underthrusted unit was absorbed by crustal folding, shortening and thickening in the Yangtze Block, forming the Xiongpo and Longquan Mountains tectonic belts and resulting in the NW-directed thrusting of the Pujiang-Chengdu-Deyang fault, and the western hillsiden fault in the Longquan Mountain. These results provide resolution to the controversy where the eastward extrusion material from the Qinghai-Tibet Plateau had gone. Overall, that Yangtze Block was subjected to thrusting of the crustal materials from the orogenic belts over its both sides. This finding has implications for the study of the intracontinental orogenic mechanism in South China, the reconstruction of tectonic evolutionary history and the kinematics processes during the lateral extrusion of the Tibet Plateau.